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The three additives are: Most fluoride additives used in the United States are produced from phosphorite rock.

updating international standards for pharmaceutical waters-45

The principles of design and operation of water systems used directly in pharmaceutical manufacturing and laboratory applications, including the essential concepts and principles of systems used to generate USP and non-compendial waters will be covered.In addition to non-compendial systems, pharmaceutical facilities typically include systems for generating USP Purified Water (PW) and USP Water-For-Injection (WFI).This course has been substantially updated to feature the guiding principles of the with particular emphasis placed upon the new chapters for microbial control and laboratory water as well as key design philosophies.Phosphorite contains calcium phosphate mixed with limestone (calcium carbonates) minerals and apatite—a mineral with high phosphate and fluoride content.It is refluxed (heated) with sulfuric acid to produce a phosphoric acid-gypsum (calcium sulfate-Ca SO4) slurry.

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