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The use of quantitative structure-activity relationships (QSAR) led to the development of other agents—starting with ranitidine, first sold as Zantac, which has fewer adverse effects and drug interactions and is more potent.-receptor antagonist from which later drugs were developed.

Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now Glaxo Smith Kline) by James W. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.

Histamine produces increased vascular permeability, causing fluid to escape from capillaries into tissues, which leads to the classic symptoms of an allergic reaction — a runny nose and watery eyes. Antihistamines suppress the histamine-induced wheal response (swelling) and flare response (vasodilation) by blocking the binding of histamine to its receptors or reducing histamine receptor activity on nerves, vascular smooth muscle, glandular cells, endothelium, and mast cells.

Antiemetics are typically used to treat motion sickness and the side effects of opioid analgesics, general anaesthetics, and chemotherapy directed against cancer.Histamine, acting on H-antihistamines help against these effects, they work only if taken before contact with the allergen.In severe allergies, such as anaphylaxis or angioedema, these effects may be of life-threatening severity.In 1964, it was known that histamine stimulated the secretion of stomach acid, and also that traditional antihistamines had no effect on acid production.From these facts the SK&F scientists postulated the existence of two different types of histamine receptors.




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In the film, she plays the role of Young-hee, an actress pondering her relationship with a married movie director while drinking together with friends in a seaside town shortly after returning from a trip to Germany."This film will hopefully bring great emotions for those who see it and therefore I'm very proud of it," Kim said during her acceptance speech.