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I've been on Seroquel before and was always sedated feeling (never got used to that).

hopefully soon i'll feel tired should i have chose the mirtazepine? Unforunetely i need quit a dose to actually feel anything. or carisprodol or meprobamate mixed with a sedative anti-histamine works well... use OTC anti-histamines for a night or two, benzos like temazepam and clonazepam another night or two, mirtazipine for a night ro two. if u have tried them feel free t list and commenton any other stuff u've tried for insomnia also get a bit og anxiety but atleast i got valiums. barbs are great but rarely Rxed due to side effects and OD risktry to rotate what you take.The most sedating drugs are the barbiturates but you won't get prescriptions for them unless you are incredibly lucky. I'm talking the fast acting ones like Secobarbital.Just wondering if someone could supply some binding affinity charts to this thread. Histamine antagonism in the brain is inherently sedating, but apparently many of the 2nd-gen antihistamines are poor at crossing the blood brain barrier, and therefore less sedating, (it depends on which one though, some 2nd-gen ones are still sedating).Adrenergic antagonism helps with sedation/anxiolysis too. A few antihistamines can have additional mechanisms of action that may add to anxiolysis/relaxation/sedation.

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