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In common use, the term "antihistamine" refers only to H In type I hypersensitivity allergic reactions, an allergen (a type of antigen) interacts with and cross-links surface Ig E antibodies on mast cells and basophils.

Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil.

In the event of an overdose or if combined with another sedative, many of these drugs can cause unconsciousness (see hypnotic) and even death.

Histamine, acting on H-antihistamines help against these effects, they work only if taken before contact with the allergen.

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Physicians and pharmacists are responsible for fully educating patients about the risks of sedating antihistamines from pharmacological points of view.

If a sedating antihistamine must be prescribed, its sedative effects should be thoroughly considered before choosing the drug.

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